Transcriptional analysis of prsA and vraTS regulatory system in methicillin resistant Staphylococcus aureus against oxacillin stress

D Bhowmik, BJ Das, M Hazarika, DD Chanda… - Indian Journal of …, 2022 - Elsevier
… both hospital and community-acquired infections. Methicillin … and also requires the two-component
regulators, namely vraS … aureus strain N315 which is null mutant of vraS/vraR showed …

… of Small Molecules Exhibiting Oxacillin Synergy through a Novel Assay for Inhibition of vraTSR Expression in Methicillin-Resistant Staphylococcus aureus

H Lee, S Boyle-Vavra, J Ren… - Antimicrobial agents …, 2019 - Am Soc Microbiol
regulator (RR) DNA binding transcriptional activator referred to generically as two-component
regulatory systems (… global regulatory system that is activated by OXA and required for the …

The dimerization interface in VraR is essential for induction of the cell wall stress response in Staphylococcus aureus: a potential druggable target

G Tajbakhsh, D Golemi-Kotra - BMC microbiology, 2019 - Springer
… , which is required for optimum binding to its target promoters. Two-component systems have
… vraRM13A did not lead to a response to oxacillin-induced stress. We had earlier suggested …

Molecular features of virulence and resistance mechanisms in nosocomial and community-acquired Staphylococcus aureus

I Gheorghe, M Popa, LG Măruţescu - Staphylococcus Aureus, 2018 - books.google.com
Methicillin-resistant Staphylococcus aureus (MRSA) strains are known for their emergent …
The vraS/vraR two-component regulatory system is required for oxacillin resistance in CA-…

The Role of Two-Component Signal Transduction Systems in Staphylococcus aureus Virulence Regulation

AF Haag, F Bagnoli - Staphylococcus aureus: Microbiology, Pathology …, 2017 - Springer
… a complex interplay with regulatory systems that respond to … protein, PBP2a mediates
oxacillin/methicillin resistance via their … does not play a role in autolysis of methicillin-resistant S. …

[PDF][PDF] The Dimerization Interface in VraR is Essential to Induction of the Cell Wall Stress Response in Staphylococcus aureus: A potential Druggable Target

D Golemi-Kotra, G Tajbakhsh - 2019 - yorkspace.library.yorku.ca
… The VraS/VraR two-component regulatory system required for oxacillin resistance in
community-acquired methicillinresistant Staphylococcus aureus. FEMS Microbiol Lett. 2006;262(2):…

Antimicrobial resistance: two-component regulatory systems and multidrug efflux pumps

GV De Gaetano, G Lentini, A Famà, F Coppolino… - Antibiotics, 2023 - mdpi.com
… the requirement of a phosphorylated response regulator [144]. … evgA up-regulation does not
determine resistance to oxacillin, … both nosocomial and community-acquired infections and is …

VraSR Regulatory System Contributes to the Virulence of Community-Associated Methicillin-Resistant Staphylococcus aureus (CA-MRSA) in a 3D-Skin Model and …

N Barua, Y Yang, L Huang, M Ip - Biomedicines, 2021 - mdpi.com
aureus (SA) expresses a wide range of virulence factors regulated by the Two-component
regulatory systems (… VraS and VraR TCR is required for resistance to cell wall antibiotics, eg, …

Detection of vancomycin nonsusceptible strains in clinical isolates of Staphylococcus aureus in northern Iran

L Asadpour, N Ghazanfari - International Microbiology, 2019 - Springer
… safest cure for methicillin-resistant Staphylococcus aureus. The … a two-component regulator
that is involved in regulating the … response regulator of the enzyme, a two-component VraSR …

Pathway-Centric Computational Approach Identifies Molecular Changes Associated with Antibiotic Resistance in Staphylococcus aureus

LK Harris - 2020 - search.proquest.com
… of oxacillin resistance gene expression datasets using KEGG have found up- regulation of
… (M00792)*, LytS-LytR twocomponent regulatory system (M00492)*, Fatty acid biosynthesis …